{"id":2719,"date":"2024-02-05T05:34:59","date_gmt":"2024-02-05T05:34:59","guid":{"rendered":"https:\/\/healthliteracyasia.com\/id\/?p=2719"},"modified":"2025-10-28T05:20:34","modified_gmt":"2025-10-28T05:20:34","slug":"deadly-dengue-virus-hacks-mosquito-saliva-to-spread-sickness","status":"publish","type":"post","link":"https:\/\/healthliteracyasia.com\/id\/2024\/02\/05\/deadly-dengue-virus-hacks-mosquito-saliva-to-spread-sickness\/","title":{"rendered":"Deadly dengue virus hacks mosquito saliva to spread sickness"},"content":{"rendered":"\n

The saliva of mosquitoes infected with dengue viruses contains a substance that thwarts the human immune system and makes it easier for people to become infected with the potentially deadly viruses, new research reveals.<\/p>\n\n\n\n

Dengue has spread in recent years to Europe and the southern United States in addition to longstanding hotspots in tropical and subtropical areas such as Southeast Asia, Africa and Latin America. The new discovery, from a University of Virginia School of Medicine scientist and his collaborators, helps explain why the disease is so easily transmitted \u2013 and could eventually lead to new ways to prevent infection.<\/p>\n\n\n\n

\u201cIt is remarkable how clever these viruses are. They subvert mosquito biology to tamp down our immune responses so that infection can take hold,\u201d said Dr. Mariano A. Garcia-Blanco, who recently joined the UVA faculty as chair of the Department of Microbiology, Immunology and Cancer Biology. \u201cThere is no doubt in my mind that a better understanding of the fundamental biology of transmission will eventually lead to effective transmission-blocking measures.\u201d<\/p>\n\n\n\n

Garcia-Blanco suspects that researchers will find similar immune-dampening substances accompanying other mosquito-borne infections such as Zika, West Nile and yellow fever. \u201cOur findings are almost certainly going to be applicable to infections with other flaviviruses,\u201d he said. \u201cThe specific molecules here are unlikely to apply to malaria, but the concept is generalizable to viral infections.\u201d<\/p>\n\n\n\n

Understanding Dengue<\/strong><\/h3>\n\n\n\n

Approximately half the world\u2019s population is at risk for dengue and roughly 400 million people are infected every year. Dengue\u2019s symptoms, including fever, nausea and skin rash, are often mistaken for other diseases. Most people will have mild cases, but about 1 in 20 will develop severe illness that can lead to shock, internal bleeding and death. Unfortunately, it\u2019s possible to contract dengue repeatedly, as it is caused by four related viruses transmitted primarily by the Aedes aegypti species of mosquito. There is no treatment, but the discovery from Garcia-Blanco and his colleagues identifies an important contributor to the disease\u2019s spread as researchers seek to find better ways to combat it.<\/p>\n\n\n\n

Garcia-Blanco and his team found that infected mosquitoes\u2019 saliva contained not just the expected dengue virus, but a powerful conspirator: molecules produced by the virus that can blunt the body\u2019s immune response. The injection of these molecules, called sfRNAs, during the mosquito bite makes it more likely that the victim will become infected with dengue, the scientists conclude.<\/p>\n\n\n\n

\u201cBy introducing this RNA at the biting site, dengue-infected saliva prepares the terrain for an efficient infection and gives the virus an advantage in the first battle between it and our immune defenses,\u201d the researchers write in a new scientific paper outlining their findings.<\/p>\n\n\n\n

Scientists who study mosquitoes previously had suspected that the insects\u2019 saliva might contain some type of payload to enhance the potential for infection. Garcia-Blanco\u2019s team\u2019s new findings pinpoint one weapon in the virus\u2019s arsenal and open the door to finding new ways to help reduce transmission and control the disease\u2019s spread. For now, the best way to avoid getting seriously sick with dengue is to avoid getting bitten.<\/p>\n\n\n\n

\u201cIncredibly, the virus can hijack these molecules so that their co-delivery at the mosquito bite site gives it an advantage in establishing an infection,\u201d said researcher Tania Strilets, a graduate student with Garcia-Blanco and co-first author of the scientific paper. \u201cThese findings provide new perspectives on how we can counteract dengue virus infections from the very first bite of the mosquito.\u201d<\/p>\n\n\n\n

Findings Published
The researchers published their findings in the scientific journal PLOS Pathogens<\/em><\/a>. The team consisted of Shih-Chia Yeh, Strilets, Wei-Lian Tan, David Castillo, Hac\u00e8ne Medkour, F\u00e9lix Rey-Cadilhac, Idalba M. Serrato-Pomar, Florian Rachenne, Avisha Chowdhury, Vanessa Chuo, Sasha R. Azar, Moirangthem Kiran Singh, Rodolphe Hamel, Doroth\u00e9e Miss\u00e9, R. Manjunatha Kini, Linda J. Kenney, Nikos Vasilakis, Marc A. Marti-Renom, Guy Nir, Julien Pompon and Garcia-Blanco. Most of Garcia-Blanco\u2019s work on the project was conducted while he was at Duke-NUS Medical School and the University of Texas Medical Branch.<\/p>\n\n\n\n

Source: University of Virginia<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The saliva of mosquitoes infected with dengue viruses contains a substance that thwarts the human immune system and makes it easier for people to become infected with the potentially deadly viruses, new research reveals. Dengue has spread in recent years to Europe and the southern United States in addition to longstanding hotspots in tropical and subtropical areas such as Southeast Asia, Africa and Latin America. The new discovery, from a University of Virginia School of Medicine scientist and his collaborators, helps explain why the disease is so easily transmitted \u2013 and could eventually lead to new ways to prevent infection. \u201cIt is remarkable how clever these viruses are. They subvert mosquito biology to tamp down our immune responses so that infection can take hold,\u201d said Dr. Mariano A. Garcia-Blanco, who recently joined the UVA faculty as chair of the Department of Microbiology, Immunology and Cancer Biology. \u201cThere is no doubt in my mind that a better understanding of the fundamental biology of transmission will eventually lead to effective transmission-blocking measures.\u201d Garcia-Blanco suspects that researchers will find similar immune-dampening substances accompanying other mosquito-borne infections such as Zika, West Nile and yellow fever. \u201cOur findings are almost certainly going to be applicable to infections with other flaviviruses,\u201d he said. \u201cThe specific molecules here are unlikely to apply to malaria, but the concept is generalizable to viral infections.\u201d Understanding Dengue Approximately half the world\u2019s population is at risk for dengue and roughly 400 million people are infected every year. Dengue\u2019s symptoms, including fever, nausea and skin rash, are often mistaken for other diseases. Most people will have mild cases, but about 1 in 20 will develop severe illness that can lead to shock, internal bleeding and death. Unfortunately, it\u2019s possible to contract dengue repeatedly, as it is caused by four related viruses transmitted primarily by the Aedes aegypti species of mosquito. There is no treatment, but the discovery from Garcia-Blanco and his colleagues identifies an important contributor to the disease\u2019s spread as researchers seek to find better ways to combat it. Garcia-Blanco and his team found that infected mosquitoes\u2019 saliva contained not just the expected dengue virus, but a powerful conspirator: molecules produced by the virus that can blunt the body\u2019s immune response. The injection of these molecules, called sfRNAs, during the mosquito bite makes it more likely that the victim will become infected with dengue, the scientists conclude. \u201cBy introducing this RNA at the biting site, dengue-infected saliva prepares the terrain for an efficient infection and gives the virus an advantage in the first battle between it and our immune defenses,\u201d the researchers write in a new scientific paper outlining their findings. Scientists who study mosquitoes previously had suspected that the insects\u2019 saliva might contain some type of payload to enhance the potential for infection. Garcia-Blanco\u2019s team\u2019s new findings pinpoint one weapon in the virus\u2019s arsenal and open the door to finding new ways to help reduce transmission and control the disease\u2019s spread. For now, the best way to avoid getting seriously sick with dengue is to avoid getting bitten. \u201cIncredibly, the virus can hijack these molecules so that their co-delivery at the mosquito bite site gives it an advantage in establishing an infection,\u201d said researcher Tania Strilets, a graduate student with Garcia-Blanco and co-first author of the scientific paper. \u201cThese findings provide new perspectives on how we can counteract dengue virus infections from the very first bite of the mosquito.\u201d Findings PublishedThe researchers published their findings in the scientific journal PLOS Pathogens. The team consisted of Shih-Chia Yeh, Strilets, Wei-Lian Tan, David Castillo, Hac\u00e8ne Medkour, F\u00e9lix Rey-Cadilhac, Idalba M. Serrato-Pomar, Florian Rachenne, Avisha Chowdhury, Vanessa Chuo, Sasha R. Azar, Moirangthem Kiran Singh, Rodolphe Hamel, Doroth\u00e9e Miss\u00e9, R. Manjunatha Kini, Linda J. Kenney, Nikos Vasilakis, Marc A. Marti-Renom, Guy Nir, Julien Pompon and Garcia-Blanco. Most of Garcia-Blanco\u2019s work on the project was conducted while he was at Duke-NUS Medical School and the University of Texas Medical Branch. Source: University of Virginia<\/p>\n","protected":false},"author":19,"featured_media":2692,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[71,1],"tags":[96,98,99,100],"class_list":["post-2719","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medical-literacy","category-news","tag-aedes-aegypti","tag-dengue","tag-mosquito","tag-sfrna"],"yoast_head":"\nDeadly dengue virus hacks mosquito saliva to spread sickness - Health Guidance Indonesia<\/title>\n<meta name=\"description\" content=\"Recent research reveals that the dengue virus manipulates mosquito saliva to suppress the human immune response, facilitating infection.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/healthliteracyasia.com\/id\/2024\/02\/05\/deadly-dengue-virus-hacks-mosquito-saliva-to-spread-sickness\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Deadly dengue virus hacks mosquito saliva to spread sickness - 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